Most of my perspective starts with this.

1. The what-is is bigger, more complex, and nonlinear than possible for homo sapiens (including myself of course) to comprehend.

2. The what-is includes Universes extending infinitely, time extending infinitely, and all not of those (for example spiritual matters, consciousness, etc, including what cannot be known is not known).

3. Therefore, be open minded!  Explore.  Enjoy the eternity of existence in every direction.